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KMID : 0861420020070020166
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Korean Journal of Nuclear Medicine Technology
2002 Volume.7 No. 2 p.166 ~ p.170
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99mTc-CIPROFLOXACIN(infecton) imaging in various clinical settings
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Kim Bong-Soo
Pyo Seong-Jae
Jo Yong-Gwi
Kim Chang-Ho
Choe Won-Sick
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Abstract
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Purpose: 99mTc-Ciprofloxacin imaging was initiated by Solanki et al (J Nucl Med 34:119p, 1993), and is an imaging method to differentiate infection from inflammation. Furthermore, it can visualize a focus of infection specific to bacterial infection. Interestingly enough, it also claims to show an area with viable, proliferating bacterial population that is actively using DNA gyrase, which the Ciprofloxacin inhibits. The aim of this study was to confirm these characteristics using our own custom-formulated 99mTc-Ciprofloxacin.
Methods and materials : 2 mg of Ciprofloxacin were mixed with 1 mg of formamidine sulfinic acid in a 10 ml sterile serum vial, and dissolved on a vortex-gene 2 for 3 minutes. Ten mCi of 99mTc were added to the vial. The air from the vial was evacuated. It was then cooled at room temperature for 20 minutes. Distilled water was added and filtered prior to intravenous injection. For quality 3, and 24-hour(in some cases) images of the whole body and/or spot views in the anterior and posterior views were obtained. SPECT images were added when necessary. We have imaged 70 patients in the following clinical settings: patients with 1)orthopedic surgical prosthesis with suspicious bacterial infection, 2) soft tissue infection, 3) female pelvic inflammatory disease(PID), 4) pulmonary tuberculosis, and 5) chronic prostatitis.
Results : We achieved a 94% labeling efficiency. 1) Excellent visualization of the peri-prosthetic infection and verification of the previous reports of others, 2) detection of bacterial infection of the soft tissue in bacteremic patients, 3) verification and localization of PIDs that corresponded to physical examination (Choe et al. Clin Nucl Med 25: 842, 2000), 4) visualization of active pulmonary tuberculosis, and 5) increased uptake in the area of the prostate in the patients compared with the normal subject were shown.
Conclusion : Our custom-formulated 99mTc-Ciprofloxacin is as valid and convenient to use as any other previously reported in visualizing bacterial infection. The data obtained in this study suggests further validation and application of this imaging method in verifying peri-prosthetic infection, soft tissue infection, PID, and exacerbation of the chronic prostatitis, and in following-up the active pulmonary tuberculosis biologically.
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KEYWORD
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Ciprofroxacin, Bacterial Infection
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